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Metabolic and cellular health represents one area of theoretical interest

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

Exp Ther Med 23:414 Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M (2021) P62/sqstm1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response

doi: 10.3390/MEDICINA56020088 2

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Studies were assessed for clarity of research design, rigour of statistical analysis, duration of follow-up, and presence of control groups